Name | L-amethopterin hydrate |
Synonyms | METHOTREXATE HYDRATE L-amethopterin hydrate (+)-AMETHOPTERIN HYDRATE (+)AMETHOPTERINE HYDRATE METHYLAMINOPTERIN HYDRATE L-(+)-AMETHOPTERIN HYDRATE 4-AMINO-10-METHYLFOLIC ACID HYDRATE L-4-AMINO-N10-METHYLPTEROYL-GLUTAMIC ACID HYDRATE L-Glutamic acid,N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, hydrate (9CI) |
CAS | 133073-73-1 |
EINECS | 625-397-3 |
InChI | InChI=1/C20H22N8O5.H2O/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30;/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27);1H2/t13-;/m0./s1 |
InChIKey | FBOZXECLQNJBKD-ZDUSSCGKSA-N |
Molecular Formula | C20H22N8O5 |
Molar Mass | 454.44 |
Melting Point | 195 °C |
Boling Point | 931.3°C at 760 mmHg |
Flash Point | 517°C |
Solubility | Easily soluble in dilute alkali, acid or alkali metal carbonate solution, slightly soluble in dilute hydrochloric acid, almost insoluble in water, ethanol, chloroform, ether. |
Vapor Presure | 0mmHg at 25°C |
Appearance | Yellow to orange powder |
Color | yellow |
Storage Condition | -20°C |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
Sensitive | `sensitive` to light and humidity |
MDL | MFCD00064370 |
Physical and Chemical Properties | Melting Point: 195 |
Use | Folic acid antagonist, dihydroxyfolate reductase (dihydrofolate reductase) inhibitor. |
Hazard Symbols | T - Toxic |
Risk Codes | R61 - May cause harm to the unborn child R25 - Toxic if swallowed R36/38 - Irritating to eyes and skin. R46 - May cause heritable genetic damage |
Safety Description | S53 - Avoid exposure - obtain special instructions before use. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36 - Wear suitable protective clothing. |
UN IDs | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS | MA1225000 |
HS Code | 29339980 |